2014 Dec 31;14:49. doi: 10.1186/s12861-014-0049-2. The heart most often weakens through the loss of muscle cells, called cardiomyocytes. Heart failure occurs when the heart cannot pump enough blood to meet the body’s demands. Please enable it to take advantage of the complete set of features! This site needs JavaScript to work properly. We use cookies to help provide and enhance our service and tailor content and ads. Zebrafish fin regeneration. In this study, zebrafish were exposed to a blast wave produced by an underwater blast wave generator. Only a few species of vertebrates display the capacity to regenerate body parts during adulthood. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. The zebrafish heart has the capacity to regenerate after ventricular resection. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. The presence of black and white stripes on the skin, gives an In fact, our biological toolkit includes the ability to regenerate some tissues. The zebrafish as a model for complex tissue regeneration. The major vault protein is dispensable for zebrafish organ regeneration. Determining the natural mechanisms behind regeneration in model organisms that regenerate well can help us develop strategies for tissue recovery in species with poor regenerative capacity (such as humans). B. For many years, the zebrafish has been used as a model in this field because of its strong regenerative capacity in organs and tissues such as the heart, retina, peripheral, and central nerves, fins, among othe… 2020 Dec 7;21(1):870. doi: 10.1186/s12864-020-07273-8. Within two weeks after amputation of a fin, a series of healing, proliferation, and patterning events replaces bone, epidermis, blood vessels, nerves, and connective tissue mesenchyme. Zebrafish … Yi Chuan. The zebrafish as a model for tissue regeneration and bone remodelling Doctoral Thesis The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. J Pathol. Toolsets continue to evolve for studies of zebrafish appendage, heart, and neural regeneration. • As is customary with genetic model … Epub 2015 Oct 27. Regeneration versus scarring in vertebrate appendages and heart. The Zebrafish as a Model of Heart Regeneration ... Regeneration is a complex biological process by which animals can restore the shape, struc-ture and function of body parts lost after injury, or after experimental amputation. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Here we review recent progress in adult regeneration paradigms in zebrafish ranging from axonal re-growth models to those of tissue regeneration. Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia. In Full Force. Figure 1. A Worthy Regeneration Model • Two features make the teleost Zebrafish a powerful, complementary model system to study organ regeneration.  |  Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. In vivo electroporation of morpholinos into the regenerating adult zebrafish tail fin. Zebrafish is an outstanding model for studying tissue regeneration [12]. Here, we studied the role of cell populations, defined by their expression of markers, in bone regeneration and remodelling in zebrafish embryos and adult zebrafish scales. The zebrafish lateral-line organ—a sensory organ used to detect the movement of water—contains superficially localized hair cells that are functionally similar to human hair cells yet are accessible in whole larval fish. COVID-19 is an emerging, rapidly evolving situation. G. Expression of genes throughout the phases of regeneration described in panels A-F are indicated schematically directly below the hallmark images. 2016 Jan ; 238 ( 2 ):29. doi: 10.3791/3632 new retinal cells... For vertebrate regeneration research heart most often weakens through the loss of muscle,... In panels A-F are indicated schematically directly below the hallmark images liver damage and then regeneration dying! Many rays of dermal bone, which further proliferate ( D ) regeneration than mammals regeneration-associated expressed! Efficiently regenerate their hearts after injury amputation, restoring both size and shape, biological... 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